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"Sanctified" is the fourth track on the 1989 release Pretty Hate Machine, recognizable by its electronic tom-based drum beat and distinctive slap bassline, the only NIN song containing that playing technique. Its mood was altered from its happier form on Purest Feeling to a darker, uneasier one for Pretty Hate Machine. Trent Reznor has said the song is about a "relationship with a crack pipe."
The album version of the song begins with a programmed drum beat featuring prominent toms and atmospheric sounds created by guitar. The body of the song is dominated by a slap bassline atop this atmosphere and drumloop, joined by strumming guitars for the chorus. The bridge features Gregorian chant samples and dialog from the film Midnight Express, though the film sample was excised on the 2010 remaster of Pretty Hate Machine. The end of the song is comprised of a synth pad and a guitar drone (created by Richard Patrick), accompanied by another sample, which lower in pitch and winds down, segueing directly into "Something I Can Never Have." On the 2010 remastered vinyl edition, this song ends the first side; as such, the ending sample is removed, and the descending synth pad fades out.

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